TRAZOSIG 50 Tablet is a pharmaceutical formulation that contains Trazodone Hydrochloride 50 mg, a widely prescribed antidepressant belonging to the class of serotonin antagonist and reuptake inhibitors (SARIs). It is primarily used for the treatment of major depressive disorder (MDD), but is also frequently prescribed for generalized anxiety disorder, chronic insomnia, and off-label uses such as managing post-traumatic stress disorder (PTSD) and fibromyalgia-related sleep disturbances.

Trazodone works by modulating the levels of serotonin, a neurotransmitter in the brain responsible for regulating mood, sleep, appetite, and emotional stability. It inhibits the reuptake of serotonin and also acts as an antagonist at certain serotonin receptors. This dual mechanism enhances the availability of serotonin in the central nervous system, helping to alleviate the symptoms of depression, anxiety, and disturbed sleep.

TRAZOSIG 50 is especially favored in clinical settings for patients who experience depression with significant sleep issues, as it possesses sedative properties without the risk of dependency seen in conventional sleep medications like benzodiazepines. Unlike many standard antidepressants, it is less likely to cause sexual dysfunction and is often used as a safer alternative when patients are sensitive to such side effects.

The tablet is usually taken orally once or twice a day, depending on the patient’s clinical condition and the prescribing physician’s recommendation. When used to treat depression or anxiety, the dose may be gradually increased to achieve optimal therapeutic effect. When prescribed for sleep disorders, it is commonly taken once at bedtime due to its calming effect.

While effective, Trazodone requires consistent use over time for the full therapeutic benefits to become apparent. Patients typically begin to notice improvement in sleep patterns within a few days, while mood-related benefits may take two to four weeks. It is important to continue the medication even if there is no immediate improvement, unless advised otherwise by a healthcare provider.

TRAZOSIG 50 is generally well-tolerated, but some individuals may experience side effects during the initial phase of treatment. Common side effects include drowsiness, dizziness, dry mouth, blurred vision, and fatigue. These effects usually lessen as the body adjusts to the medication. Rare but serious side effects include orthostatic hypotension, priapism (a prolonged erection), and serotonin syndrome, especially when used in combination with other serotonergic drugs.

This medication should not be combined with monoamine oxidase inhibitors (MAOIs), and a gap of at least two weeks is recommended between stopping an MAOI and starting Trazodone. It should be used cautiously in individuals with a history of heart disease, particularly those with arrhythmias or recent myocardial infarction, due to its potential to affect cardiac rhythm.

TRAZOSIG 50 is not approved for use in children and adolescents under 18 years of age for depression, due to an increased risk of suicidal thoughts in this population. Patients and caregivers should remain vigilant for any changes in behavior, mood, or suicidal ideation, especially in the early stages of treatment or when doses are adjusted.

Alcohol consumption should be avoided during treatment, as it may intensify the sedative effects of Trazodone and increase the risk of central nervous system depression. Patients should also avoid activities requiring mental alertness, such as driving or operating machinery, until they know how the medication affects them.

Pregnant or breastfeeding women should only use TRAZOSIG 50 if clearly needed and prescribed by a doctor. Although there is limited evidence of harm, its use during pregnancy should be carefully considered, especially during the third trimester.

The tablet is manufactured in facilities that adhere to Good Manufacturing Practice (GMP) and other international regulatory standards, ensuring quality, potency, and safety in every batch. Each tablet is formulated to deliver consistent absorption and bioavailability, making it a dependable choice for physicians and patients alike.