ESARTAN AP TAB, proudly manufactured by BluepillExpress, is a powerful triple combination antihypertensive therapy engineered for patients who fail to achieve optimal blood pressure control on dual drug regimens. This once-daily oral tablet combines three well-established antihypertensive agents—Telmisartan, Amlodipine, and Hydrochlorothiazide—each targeting a unique physiological pathway to ensure comprehensive blood pressure reduction and end-organ protection.

Telmisartan is a potent ARB (angiotensin II receptor blocker) that prevents vasoconstriction and aldosterone-mediated sodium retention by blocking angiotensin II at its receptor site. It offers a long half-life, enabling sustained 24-hour blood pressure control.

Amlodipine, a dihydropyridine calcium channel blocker, induces peripheral vasodilation by inhibiting calcium influx into smooth muscle cells, thereby lowering systemic vascular resistance.

Hydrochlorothiazide (HCTZ) is a thiazide diuretic that reduces blood volume and vascular resistance by enhancing sodium and water excretion from the distal convoluted tubules.

Together, these three agents provide synergistic control over systolic and diastolic pressure, and significantly improve arterial compliance, stroke volume, and renal outcomes, especially in high-risk populations.

✅ Therapeutic Indications

Stage II or Resistant Hypertension

High-risk cardiovascular hypertensive patients

Diabetic hypertensives with renal risk

Hypertension unresponsive to dual therapy

Post-stroke or post-MI hypertensive management

✅ Mechanism of Action

Telmisartan: Inhibits AT1 receptors → vasodilation and reduced aldosterone levels

Amlodipine: Blocks calcium entry → smooth muscle relaxation and reduced resistance

HCTZ: Inhibits Na+/Cl− co-transporter → decreased plasma volume and BP

This triple-action ensures maximum antihypertensive efficacy while minimizing side effects through lower individual doses.