ESARTAN AM TAB, manufactured by BluepillExpress, is a dual-action antihypertensive tablet designed to deliver superior and sustained blood pressure control through the synergistic combination of Telmisartan 40 mg and Amlodipine 5 mg. This combination targets hypertension from two critical pathways: renin-angiotensin blockade and vasodilation via calcium channel inhibition.

Telmisartan, a potent ARB (angiotensin II receptor blocker), reduces peripheral vascular resistance by preventing angiotensin II from binding to its receptors, thereby relaxing blood vessels and lowering blood pressure without affecting heart rate. It is known for its long half-life, allowing 24-hour BP control and improved patient adherence.

Amlodipine is a well-established calcium channel blocker that relaxes and widens blood vessels by inhibiting calcium influx into vascular smooth muscle cells. This effect reduces systemic vascular resistance and improves blood flow, contributing significantly to systolic and diastolic pressure reductions.

ESARTAN AM TAB offers a convenient once-daily oral dosing that enhances treatment adherence, reduces pill burden, and minimizes fluctuations in blood pressure throughout the day and night. Its complementary mechanisms make it ideal for patients who do not achieve target BP goals with monotherapy.

The product is manufactured in WHO-GMP certified facilities with a focus on quality, purity, and compliance. With robust stability data, global regulatory documentation, and customizable packaging, ESARTAN AM TAB is ready for export across Asia, Africa, LATAM, CIS, and Middle East regions.

✅ Indications / Therapeutic Uses

Essential Hypertension (Stage 1 & 2)

Resistant Hypertension

Hypertension with left ventricular hypertrophy (LVH)

Cardiovascular risk reduction

Post-stroke secondary prevention (as per physician advice)

High-risk hypertensive diabetic patients

✅ Mechanism of Action

Telmisartan: Blocks the binding of angiotensin II to AT1 receptors, inhibiting vasoconstriction, aldosterone secretion, and sympathetic activation.

Amlodipine: Inhibits L-type calcium channels, leading to vasodilation and reduced peripheral resistance, without negative inotropic effects.

This dual mechanism helps in reducing both systolic and diastolic BP and improves overall cardiovascular hemodynamics.

✅ Pharmacokinetic Highlights

Telmisartan

Oral Bioavailability: ~50%

Half-life: 24 hours

Metabolism: Hepatic (non-CYP dependent)

Excretion: Bile and feces

Amlodipine

Oral Bioavailability: ~60-65%

Half-life: 30–50 hours

Metabolism: Hepatic via CYP3A4

Excretion: Urine