DERMAFIL Tablet is a high-efficacy, oral retinoid formulation containing Isotretinoin, a synthetic derivative of Vitamin A that revolutionized the treatment of severe cystic or recalcitrant acne, commonly referred to as nodular acne or acne conglobata. It is one of the most powerful oral acne treatments available today and is used worldwide in dermatology.

DERMAFIL is meticulously manufactured by BluepillExpress, a trusted name in third-party pharmaceutical production and export. Our manufacturing process complies with WHO-GMP, ISO 9001:2015, and Schedule H drug guidelines, ensuring every batch meets the highest standards of safety, stability, and therapeutic value. We offer the product for both domestic distribution and international export with customizable labeling and documentation.

Pharmacological Overview

Active Ingredient: Isotretinoin

Mechanism of Action: Reduces sebaceous gland size and function, prevents abnormal keratinization, inhibits inflammation and bacterial colonization

Bioavailability: Increased when taken with food

Metabolism: Hepatic (primarily via cytochrome P450 system)

Excretion: Via feces and urine

Indications

DERMAFIL Tablet is specifically indicated for:

Severe nodular acne (nodulocystic acne)

Acne resistant to conventional treatments (topical and systemic antibiotics)

Acne conglobata

Acne with risk of permanent scarring

Inflammatory acne vulgaris

Off-label uses may include: Rosacea, folliculitis, and seborrheic dermatitis in select cases under medical supervision.

Dosage & Administration

Typical Adult Dose: 0.5–1 mg/kg/day in divided doses for 15–20 weeks

Maximum Cumulative Dose: Around 120–150 mg/kg over entire treatment course

Administration: Orally with meals for better absorption

Treatment Duration: Usually 4–6 months or until 70% improvement is achieved

Retreatment: May be repeated after 2 months if necessary

Note: Dose adjustments should always be determined by a dermatologist based on patient tolerance and response.