COLCHICINE 0.5 mg Tablet, offered by BluepillExpress, is a well-established, effective oral treatment for gouty arthritis, particularly in the acute phase and for prophylactic use. Derived from the natural alkaloid found in the plant Colchicum autumnale, Colchicine has a long-standing history in medicine for over 2,000 years. Today, it remains a cornerstone therapy for gout, pericarditis, and autoinflammatory disorders such as familial Mediterranean fever (FMF).

This tablet contains Colchicine USP 0.5 mg in a stable, easily absorbable oral formulation that inhibits the inflammatory response to monosodium urate crystals in joints. It is particularly valued for its dual role—both in acute management and chronic prophylaxis of gout flares.

Mechanism of Action:

Colchicine works by:

Inhibiting microtubule polymerization, thereby disrupting leukocyte migration and phagocytosis of uric acid crystals.

Reducing chemotactic factors and preventing the release of inflammatory mediators.

Interfering with the assembly of the inflammasome complex that activates interleukin-1β (IL-1β), a key cytokine in gout inflammation.

By interrupting the inflammatory cascade, Colchicine effectively alleviates joint pain, redness, and swelling.

Pharmaceutical Composition:

Each tablet contains:

Colchicine USP 0.5 mg

Other excipients: Lactose monohydrate, magnesium stearate, microcrystalline cellulose, and other pharmaceutically approved agents for tablet formulation.

Indications:

Colchicine 0.5 mg Tablet is indicated for:

Treatment of acute gouty arthritis

Prophylaxis of gout flares during uric acid-lowering therapy

Familial Mediterranean Fever (FMF)

Pericarditis (off-label, as part of guideline-supported management)

Behçet’s disease (off-label)

Investigational use in COVID-19 cytokine storm (in some clinical protocols)

Dosage and Administration:

Acute gout flare: 1.2 mg at the first sign of flare, followed by 0.6 mg one hour later. Not to exceed 1.8 mg in 1 hour.

Prophylaxis: 0.5–1 mg daily, usually in divided doses.

Familial Mediterranean Fever: 1–2 mg per day in divided doses.

Dosage may vary based on renal or hepatic function and patient age.

Key Benefits:

Fast-acting relief from acute gout symptoms

Effective long-term flare prevention

Well-researched and clinically validated molecule

Low-dose formulation (0.5 mg) reduces gastrointestinal side effects

Manufactured to international pharmacopeia standards

Available for bulk export, third-party manufacturing, and custom branding

Side Effects:

Common: Nausea, vomiting, diarrhea, abdominal pain

Rare but serious: Myopathy, bone marrow suppression, neuromyopathy, liver toxicity

Long-term use should be monitored for toxicity and blood counts, especially in patients with kidney or liver impairment