CLOZOLE-CL Vaginal Suppository Soft Gelatin Capsule is a potent combination formulation intended for the effective treatment of mixed vaginal infections, especially those caused by the co-existence of bacterial vaginosis (BV) and vaginal candidiasis (VC). The combination of Clindamycin Phosphate (a lincosamide antibiotic) and Clotrimazole (an antifungal agent) provides a broad antimicrobial spectrum that covers both anaerobic bacteria and fungal pathogens, ensuring complete resolution of infection and inflammation.

The soft gelatin suppository format allows for direct intravaginal delivery of the active ingredients, enabling localized treatment with higher drug concentrations at the infection site while minimizing systemic exposure and adverse effects. This formulation is ideal for patients who prefer localized therapy over oral or injectable alternatives and is particularly beneficial in treating non-specific vaginitis, mixed vaginal flora infections, and recurrent vulvovaginal candidiasis.

Mechanism of Action:

Clindamycin Phosphate works by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit. It is highly effective against anaerobic bacteria and Gram-positive organisms, including Gardnerella vaginalis, which is often implicated in bacterial vaginosis. Clindamycin significantly reduces the overgrowth of harmful bacteria while restoring the natural balance of vaginal flora.

Clotrimazole is an imidazole antifungal that interferes with fungal cell membrane permeability by inhibiting ergosterol synthesis. It is particularly effective against Candida albicans and other non-albicans species. By disrupting fungal cell integrity, clotrimazole rapidly eliminates fungal colonization and controls the symptoms of itching, discharge, and discomfort.

Together, these agents provide dual benefits: clindamycin treats the bacterial component of the infection, while clotrimazole eradicates the fungal cause, making CLOZOLE-CL a comprehensive solution for women suffering from dual or overlapping vaginal infections.

Therapeutic Applications:

Mixed vaginal infections (Bacterial + Fungal)

Bacterial Vaginosis (BV)

Vulvovaginal Candidiasis (VC)

Vaginitis due to Gardnerella vaginalis and Candida species

Post-antibiotic secondary fungal infections

Recurrent vaginal discharge or itching of infectious origin

Advantages of CLOZOLE-CL Soft Gelatin Suppository:

Localized therapy minimizes systemic side effects

Faster onset of action and high efficacy at the site of infection

Convenient once-daily intravaginal administration

Gentle on the mucosa with minimal irritation

Ideal for women with GI sensitivity or systemic antibiotic intolerance