CLOMISIGN 100 Tablet is a high-dose formulation of Clomiphene Citrate, a widely accepted Selective Estrogen Receptor Modulator (SERM) that acts on the hypothalamic-pituitary-ovarian axis to stimulate ovulation in women with infertility related to ovulatory dysfunction.

Manufactured by BluepillExpress, a globally reputed pharmaceutical company based in India, CLOMISIGN 100 is a quality-assured product that complies with international regulatory norms, ideal for third-party manufacturing, global distribution, and private labeling.

Pharmacological Profile:

Mechanism of Action:

Clomiphene works by binding to estrogen receptors in the hypothalamus, blocking negative feedback from endogenous estrogens. This leads to increased secretion of gonadotropin-releasing hormone (GnRH), which stimulates the release of FSH and LH, hormones essential for follicular development and ovulation.

The 100 mg dose is typically used in patients who fail to ovulate or conceive with the standard 50 mg regimen.

Indications:

CLOMISIGN 100 is indicated for the treatment of:

Anovulatory infertility, especially due to PCOS

Luteal phase defect

Unexplained infertility as part of fertility protocols

Induction of ovulation for timed intercourse or intrauterine insemination (IUI)

Adjunct in some cases of male infertility (off-label use)

Formulation:

Each film-coated tablet contains:

Clomiphene Citrate IP – 100 mg

Pharmaceutical-grade excipients ensure optimal tablet disintegration and bioavailability.

Dosage and Administration:

Typically prescribed once daily for 5 days, starting on Day 2 to Day 5 of the menstrual cycle

Usually initiated after no ovulatory response is seen from a 50 mg course

Ovulation generally occurs 5–10 days after the last tablet

Should not be continued for more than 6 cycles without reassessment

Medical supervision with ultrasound monitoring is recommended to minimize the risk of ovarian hyperstimulation or multiple pregnancies.